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Peptide record

TPDB20673

Antibacterial Anticancer Antifungal Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB20673
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb
standard
No
A 39-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Sequence
GSKRWRKFEKRVKKIFEETKEALPVVQGVVGVATAVGRK
Physicochemical Analysis
C200H336N60O52
NDCHMY
KV
4413.24
11.18
11
4
15
+7
14.73
-0.523
79.74
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
124.63
4
Residue Composition
number
3
A
4
R
0
N
0
D
0
C
4
E
1
Q
4
G
0
H
1
I
1
L
7
K
0
M
2
F
1
P
1
S
2
T
1
W
0
Y
7
V
Amino Acid Distribution
A: 3 R: 4 N: 0 D: 0 C: 0 E: 4 Q: 1 G: 4 H: 0 I: 1 L: 1 K: 7 M: 0 F: 2 P: 1 S: 1 T: 2 W: 1 Y: 0 V: 7
Chemical Descriptors
39
C200H336N60O52
4413.24
11.18
+7
14.73
-0.523
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

Escherichia coli ATCC 25922 or ATCC 35218

Source & Reference

NA

Other

active against Gram- E. coli ATCC 25922 or ATCC 35218 (MIC 6.25 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/m
Evidence 2 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

Pseudomonas aeruginosa ATCC 105663

Source & Reference

NA

Other

active against Gram- E. coli ATCC 25922 or ATCC 35218 (MIC 6.25 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml
Evidence 3 Activity

Activity

MIC
Antibacterial
3.12 µg/mL

Target

Klebsiella pneumoniae ATCC BAA 170513

Source & Reference

NA

Other

li ATCC 25922 or ATCC 35218 (MIC 6.25 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml), E.faecalis ATCC 29212 (MIC >100 ug/ml), fungi
Evidence 4 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

S.aureus ATCC 29213

Source & Reference

NA

Other

inosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml), E.faecalis ATCC 29212 (MIC >100 ug/ml), fungi C.parapsilosis ATCC 22019 (MIC >100 ug/ml)
Evidence 5 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

NA

Other

. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml), E.faecalis ATCC 29212 (MIC >100 ug/ml), fungi C.parapsilosis ATCC 22019 (MIC >100 ug/ml).
Evidence 6 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

C.parapsilosis ATCC 22019

Source & Reference

NA

Other

Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml), E.faecalis ATCC 29212 (MIC >100 ug/ml), fungi C.parapsilosis ATCC 22019 (MIC >100 ug/ml).
Evidence 7 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

Escherichia coli ATCC 25922 or ATCC 35218

Source & Reference

CAFPdb

Other

active against Gram- E. coli ATCC 25922 or ATCC 35218 (MIC 6.25 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/m
Evidence 8 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

Pseudomonas aeruginosa ATCC 105663

Source & Reference

CAFPdb

Other

active against Gram- E. coli ATCC 25922 or ATCC 35218 (MIC 6.25 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml
Evidence 9 Activity

Activity

MIC
Antifungal
3.12 µg/mL

Target

Klebsiella pneumoniae ATCC BAA 170513

Source & Reference

CAFPdb

Other

li ATCC 25922 or ATCC 35218 (MIC 6.25 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml), E.faecalis ATCC 29212 (MIC >100 ug/ml), fungi
Evidence 10 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

S.aureus ATCC 29213

Source & Reference

CAFPdb

Other

inosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml), E.faecalis ATCC 29212 (MIC >100 ug/ml), fungi C.parapsilosis ATCC 22019 (MIC >100 ug/ml)
Evidence 11 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

CAFPdb

Other

. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml), E.faecalis ATCC 29212 (MIC >100 ug/ml), fungi C.parapsilosis ATCC 22019 (MIC >100 ug/ml).
Evidence 12 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

C.parapsilosis ATCC 22019

Source & Reference

CAFPdb

Other

Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml), E.faecalis ATCC 29212 (MIC >100 ug/ml), fungi C.parapsilosis ATCC 22019 (MIC >100 ug/ml).
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
496.8 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 496.8 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles. | Peptides | 2021
Evidence 14 Activity

Activity

IC50
Toxicity
>500 µg/mL
Cytotoxic
IC50 | >500 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles. | Peptides | 2021
Evidence 15 Activity

Activity

IC50
Toxicity
>500 µg/mL
Cytotoxic
IC50 | >500 | µg/mL | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles. | Peptides | 2021
Evidence 16 Activity

Activity

IC50
Toxicity
>500 µg/mL
Cytotoxic
IC50 | >500 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles. | Peptides | 2021