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Peptide record

TPDB20672

Antibacterial Anticancer Antifungal Toxicity standard

38 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB20672

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 38-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.

Sequence

GSKRWRKFEKRVKKIFEETKEALPVIQGVATIVGAVGR

FASTA

>TPDB20672|Antibacterial;Anticancer;Antifungal;Toxicity|length=38
GSKRWRKFEKRVKKIFEETKEALPVIQGVATIVGAVGR

Formula C196H328N58O51

Absent Amino Acids NDCHMY

Common Amino Acids K

Mass 4313.12

PI 11.12

Basic Residues 10

Acidic Residues 4

Hydrophobic Residues 15

Net Charge +6

Boman Index 12.98

Hydrophobicity -0.418

Aliphatic Index 87.11

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 127.52

Polar Residues 4

number

Amino Acid Distribution

A: 3 R: 4 N: 0 D: 0 C: 0 E: 4 Q: 1 G: 4 H: 0 I: 3 L: 1 K: 6 M: 0 F: 2 P: 1 S: 1 T: 2 W: 1 Y: 0 V: 5

Length

Formula

C196H328N58O51

Mass

4313.12

11.12

Net Charge

Boman Index

12.98

Hydrophobicity

-0.418

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µg/mL

Target

Target Organism Escherichia coli ATCC 25922 or ATCC 35218

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram- E. coli ATCC 25922 or ATCC 35218 (MIC 6.25 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 6.25 ug/m

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC 105663

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram- E. coli ATCC 25922 or ATCC 35218 (MIC 6.25 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 6.25 ug/ml), Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µg/mL

Target

Target Organism Klebsiella pneumoniae ATCC BAA 170513

Source & Reference

Database Source NA

Other

Evidence Text

li ATCC 25922 or ATCC 35218 (MIC 6.25 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 6.25 ug/ml), Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml), E.faecalis ATCC 29212 (MIC >100 ug/ml), fungi

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

inosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 6.25 ug/ml), Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml), E.faecalis ATCC 29212 (MIC >100 ug/ml), fungi C.parapsilosis ATCC 22019 (MIC >100 ug/ml)

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism Enterococcus faecalis ATCC 29212

Source & Reference

Database Source NA

Other

Evidence Text

. pneumoniae ATCC BAA 170513 (MIC 6.25 ug/ml), Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml), E.faecalis ATCC 29212 (MIC >100 ug/ml), fungi C.parapsilosis ATCC 22019 (MIC >100 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism C.parapsilosis ATCC 22019

Source & Reference

Database Source NA

Other

Evidence Text

Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml), E.faecalis ATCC 29212 (MIC >100 ug/ml), fungi C.parapsilosis ATCC 22019 (MIC >100 ug/ml).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µg/mL

Target

Target Organism Escherichia coli ATCC 25922 or ATCC 35218

Source & Reference

Database Source CAFPdb

Other

Evidence Text

active against Gram- E. coli ATCC 25922 or ATCC 35218 (MIC 6.25 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 6.25 ug/m

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC 105663

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µg/mL

Target

Target Organism Klebsiella pneumoniae ATCC BAA 170513

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus ATCC 29213

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism Enterococcus faecalis ATCC 29212

Source & Reference

Database Source CAFPdb

Other

Evidence Text

. pneumoniae ATCC BAA 170513 (MIC 6.25 ug/ml), Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml), E.faecalis ATCC 29212 (MIC >100 ug/ml), fungi C.parapsilosis ATCC 22019 (MIC >100 ug/ml).

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism C.parapsilosis ATCC 22019

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Gram+ S.aureus ATCC 29213 (MIC>100 ug/ml), E.faecalis ATCC 29212 (MIC >100 ug/ml), fungi C.parapsilosis ATCC 22019 (MIC >100 ug/ml).

Evidence 13 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 321.1 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 321.1 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles. | Peptides | 2021

Evidence 14 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 268.4 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 268.4 | µg/mL | target cell: Vero cells

Target

Target Cell Vero cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles. | Peptides | 2021

Evidence 15 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 424.9 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 424.9 | µg/mL | target cell: Human PBMC

Target

Target Cell Human PBMC

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles. | Peptides | 2021

Evidence 16 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement >500 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | >500 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles. | Peptides | 2021

Evidence 17 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2021 Nov 145:170627.