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Peptide record

TPDB20666

Antibacterial Toxicity modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB20666
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 18-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
GRVPIIYTNRKXGVCKRM
Physicochemical Analysis
C86H151N29O21S2
ADEQHLFSW
R
1991.45
11.41
5
0
6
+5
3.55
-0.411
75.56
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
74.82
4
Residue Composition
number
0
A
3
R
1
N
0
D
1
C
0
E
0
Q
2
G
0
H
2
I
0
L
2
K
1
M
0
F
1
P
0
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 0 K: 2 M: 1 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
18
C86H151N29O21S2
1991.45
11.41
+5
3.55
-0.411
Evidence Records 2 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
0% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Semisynthetic Macrocyclic Lipo-lanthipeptides Display Antimicrobial Activity Against Bacterial Pathogens. | ACS Synth Biol | 2021
Evidence 2 Activity

Activity

2.4±0.9% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
2.4±0.9% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Semisynthetic Macrocyclic Lipo-lanthipeptides Display Antimicrobial Activity Against Bacterial Pathogens. | ACS Synth Biol | 2021