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Peptide record

TPDB20665

Antibacterial Antifungal Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB20665
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia AFP-GFuse Antifungipept CAFPdb DRAMP dbAMP ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, AFP-GFuse, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GRTSKQELCTWERGSVRQADKTIAG
Physicochemical Analysis
C115H193N39O39S1
NHMFPY
RGT
2778.10
9.90
5
3
6
+2
8.32
-1.040
50.80
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
197.98
8
Residue Composition
number
2
A
3
R
0
N
1
D
1
C
2
E
2
Q
3
G
0
H
1
I
1
L
2
K
0
M
0
F
0
P
2
S
3
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 1 C: 1 E: 2 Q: 2 G: 3 H: 0 I: 1 L: 1 K: 2 M: 0 F: 0 P: 0 S: 2 T: 3 W: 1 Y: 0 V: 1
Chemical Descriptors
25
C115H193N39O39S1
2778.10
9.90
+2
8.32
-1.040
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
21.6 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against C. albicans ATCC 10231 (MIC 21.6 uM), C. krusei DSM 70079 (MIC 20.7 uM), C. glabrata ATCC 90030 (MIC 19.8 uM), A. niger ATCC 9
Evidence 2 Activity

Activity

MIC
Antibacterial
20.7 µM

Target

C. krusei DSM 70079

Source & Reference

dbAMP DRAMP

Other

Active against C. albicans ATCC 10231 (MIC 21.6 uM), C. krusei DSM 70079 (MIC 20.7 uM), C. glabrata ATCC 90030 (MIC 19.8 uM), A. niger ATCC 9029 (MIC 22.5 uM), A. flavus PFCC 1
Evidence 3 Activity

Activity

MIC
Antibacterial
19.8 µM

Target

C. glabrata ATCC 90030

Source & Reference

dbAMP DRAMP

Other

Active against C. albicans ATCC 10231 (MIC 21.6 uM), C. krusei DSM 70079 (MIC 20.7 uM), C. glabrata ATCC 90030 (MIC 19.8 uM), A. niger ATCC 9029 (MIC 22.5 uM), A. flavus PFCC 100 (MIC 23.4 uM), and A. fumigatus Af
Evidence 4 Activity

Activity

MIC
Antibacterial
22.5 µM

Target

A. niger ATCC 9029

Source & Reference

dbAMP DRAMP

Other

1 (MIC 21.6 uM), C. krusei DSM 70079 (MIC 20.7 uM), C. glabrata ATCC 90030 (MIC 19.8 uM), A. niger ATCC 9029 (MIC 22.5 uM), A. flavus PFCC 100 (MIC 23.4 uM), and A. fumigatus Af 293 (MIC 20.7 uM). Provided by Had
Evidence 5 Activity

Activity

MIC
Antibacterial
23.4 µM

Target

A. flavus PFCC 100

Source & Reference

dbAMP DRAMP

Other

79 (MIC 20.7 uM), C. glabrata ATCC 90030 (MIC 19.8 uM), A. niger ATCC 9029 (MIC 22.5 uM), A. flavus PFCC 100 (MIC 23.4 uM), and A. fumigatus Af 293 (MIC 20.7 uM). Provided by Hadi Zare-Zardini. Updated 10/2023
Evidence 6 Activity

Activity

MIC
Antibacterial
20.7 µM

Target

A. fumigatus Af 293

Source & Reference

dbAMP DRAMP

Other

30 (MIC 19.8 uM), A. niger ATCC 9029 (MIC 22.5 uM), A. flavus PFCC 100 (MIC 23.4 uM), and A. fumigatus Af 293 (MIC 20.7 uM). Provided by Hadi Zare-Zardini. Updated 10/2023
Evidence 7 Activity

Activity

MIC
Antifungal
21.6 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
Active against C. albicans ATCC 10231 (MIC 21.6 uM), C. krusei DSM 70079 (MIC 20.7 uM), C. glabrata ATCC 90030 (MIC 19.8 uM), A. niger ATCC 9
Evidence 8 Activity

Activity

MIC
Antifungal
20.7 µM

Target

C. krusei DSM 70079

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against C. albicans ATCC 10231 (MIC 21.6 uM), C. krusei DSM 70079 (MIC 20.7 uM), C. glabrata ATCC 90030 (MIC 19.8 uM), A. niger ATCC 9029 (MIC 22.5 uM), A. flavus PFCC 1
Evidence 9 Activity

Activity

MIC
Antifungal
19.8 µM

Target

C. glabrata ATCC 90030

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against C. albicans ATCC 10231 (MIC 21.6 uM), C. krusei DSM 70079 (MIC 20.7 uM), C. glabrata ATCC 90030 (MIC 19.8 uM), A. niger ATCC 9029 (MIC 22.5 uM), A. flavus PFCC 100 (MIC 23.4 uM), and A. fumigatus Af
Evidence 10 Activity

Activity

MIC
Antifungal
22.5 µM

Target

A. niger ATCC 9029

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

1 (MIC 21.6 uM), C. krusei DSM 70079 (MIC 20.7 uM), C. glabrata ATCC 90030 (MIC 19.8 uM), A. niger ATCC 9029 (MIC 22.5 uM), A. flavus PFCC 100 (MIC 23.4 uM), and A. fumigatus Af 293 (MIC 20.7 uM). Provided by Had
Evidence 11 Activity

Activity

MIC
Antifungal
23.4 µM

Target

A. flavus PFCC 100

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

79 (MIC 20.7 uM), C. glabrata ATCC 90030 (MIC 19.8 uM), A. niger ATCC 9029 (MIC 22.5 uM), A. flavus PFCC 100 (MIC 23.4 uM), and A. fumigatus Af 293 (MIC 20.7 uM). Provided by Hadi Zare-Zardini. Updated 10/2023
Evidence 12 Activity

Activity

MIC
Antifungal
20.7 µM

Target

A. fumigatus Af 293

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

30 (MIC 19.8 uM), A. niger ATCC 9029 (MIC 22.5 uM), A. flavus PFCC 100 (MIC 23.4 uM), and A. fumigatus Af 293 (MIC 20.7 uM). Provided by Hadi Zare-Zardini. Updated 10/2023
Evidence 13 Activity

Activity

0.19% Hemolysis
Toxicity
3.6 µM
Hemolytic Cytotoxic
0.19% Hemolysis | 3.6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Isolation and functional characterization of an antifungal hydrophilic peptide, Skh-AMP1, derived from Satureja khuzistanica leaves. | Phytochemistry | 2019
Evidence 14 Activity

Activity

2.1% Hemolysis
Toxicity
72 µM
Hemolytic Cytotoxic
2.1% Hemolysis | 72 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Isolation and functional characterization of an antifungal hydrophilic peptide, Skh-AMP1, derived from Satureja khuzistanica leaves. | Phytochemistry | 2019
Evidence 15 Activity

Activity

3.6% Cytotoxicity
Toxicity
25.2 µM
Cytotoxic
3.6% Cytotoxicity | 25.2 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Isolation and functional characterization of an antifungal hydrophilic peptide, Skh-AMP1, derived from Satureja khuzistanica leaves. | Phytochemistry | 2019
Evidence 16 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31128493] Using human erythrocytes, the hemolytic activity of Skh-AMP1 at concentrations from 3.6 µM to 72 µM was reported in the range of 0.19%–2.1%. At the MIC concentration of 25.2 µM, a very low hemolytic activity of 0.67% (SD = 0.02) was observed. Also, this peptide at MFC concentrations (36, 54 and 72 µM) showed 0.98%, 1.45% and 2.1% hemolytic activity for human erythrocytes. | Cytotoxicity: [Ref.31128493] Skh-AMP1 has about 3.6% cytotoxicity at the concentration of 25.2 µM in 48 h. Therefore, this peptide had no significant cytotoxic effect at the concentrations of 12.6 and 25.2 µM at 6, 24, and 48 h. However, Skh-AMP1 has about 12% and 27% cytotoxicity at the concentration of 50.4 µM and 63 µM, respectively

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2020 Jan 123:170195. doi: 10.1016/j.peptides.2019.170195. Epub 2019 Nov 6.##Phytochemistry. 2019 Aug 164:136-143. doi: 10.1016/j.phytochem.2019.05.011. Epub 2019 May 23.