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Peptide record

TPDB20582

Antibacterial Antiviral Toxicity modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB20582
Antibacterial Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia dbAMP 3.0 DRAVP 2.0
modified_plain
Yes
A 18-aa modified multi-activity (Antibacterial, Antiviral, and Toxicity) peptide sequence curated from Peptipedia, dbAMP 3.0, and DRAVP 2.0, with an available 3D structural model.
Modified, details unspecified
Sequence
GRFKRXRKKXKKLFKKIS
Physicochemical Analysis
C95H170N32O18
ANDCEQHMPTWYV
K
2048.60
12.73
10
0
4
+10
6.37
-1.561
43.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
1
L
7
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 7 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C95H170N32O18
2048.60
12.73
+10
6.37
-1.561
Evidence Records 2 records
Evidence 1 Activity

Activity

50% cell death
Toxicity
10.2 µM
Cytotoxic
50% cell death | 10.2 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins | Antimicrob Agents Chemother | 2008
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.18591279]CEM-SS cells:TC50=10.2 µM.(TC50:the concentration that reduced cell viability by 50%)

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2008 Sep 52(9):3438-40.