Back to search

Peptide record

TPDB20570

Antibacterial Anticancer Antifungal Toxicity modified_plain modified
36 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB20570
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb
modified_plain
Yes
A 36-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Modified, details unspecified
Sequence
GPKTKAACKXACKLATCGKKPGGWKCKLCELGCDAV
Physicochemical Analysis
C152H260N44O42S6
RNQHIMFSY
K
3568.37
9.23
8
2
10
+6
6.65
-0.169
54.44
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
164.64
8
Residue Composition
number
5
A
0
R
0
N
1
D
6
C
1
E
0
Q
5
G
0
H
0
I
3
L
8
K
0
M
0
F
2
P
0
S
2
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 0 N: 0 D: 1 C: 6 E: 1 Q: 0 G: 5 H: 0 I: 0 L: 3 K: 8 M: 0 F: 0 P: 2 S: 0 T: 2 W: 1 Y: 0 V: 1
Chemical Descriptors
36
C152H260N44O42S6
3568.37
9.23
+6
6.65
-0.169
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Toxicity
4.8 µM
Cytotoxic
IC50 | 4.8 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Isolation and Characterization of Antimicrobial Peptides With Unusual Disulfide Connectivity From the Colonial Ascidian Synoicum turgens | Mar Drugs | 2020
Evidence 2 Activity

Activity

IC50
Toxicity
4.8 µM
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: MRC-5: IC50=4.8 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Mar Drugs. 2020 Jan 12 18(1):51.