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Peptide record

TPDB20458

Antibacterial Anticancer Antifungal Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB20458
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GLWNSIKIAGKKLFVNVLDKIR
Physicochemical Analysis
C118H198N32O28
CEQHMPTY
K
2513.07
10.98
5
1
11
+4
1.37
0.218
137.27
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
218.86
3
Residue Composition
number
1
A
1
R
2
N
1
D
0
C
0
E
0
Q
2
G
0
H
3
I
3
L
4
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 4 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
22
C118H198N32O28
2513.07
10.98
+4
1.37
0.218
Evidence Records 4 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
87.304 µM
Hemolytic Cytotoxic
10% Hemolysis | 87.304 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Targeted Modification and Structure-Activity Study of GL-29, an Analogue of the Antimicrobial Peptide Palustrin-2ISb. | Antibiotics (Basel) | 2022
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
254.11 µM
Hemolytic Cytotoxic
50% Hemolysis | 254.11 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Targeted Modification and Structure-Activity Study of GL-29, an Analogue of the Antimicrobial Peptide Palustrin-2ISb. | Antibiotics (Basel) | 2022
Evidence 3 Activity

Activity

IC50
Toxicity
38.9 µM
Cytotoxic
IC50 | 38.9 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Targeted Modification and Structure-Activity Study of GL-29, an Analogue of the Antimicrobial Peptide Palustrin-2ISb. | Antibiotics (Basel) | 2022
Evidence 4 Activity

Activity

IC50
Toxicity
38.90 µM
Hemolytic Cytotoxic
Hemolytic_activity: Horse erythrocytes: 10% Hemolysis=87.304 µM 50% Hemolysis=254.11 µM | Cytotoxicity: Human keratinocytes HaCat: IC50=38.90 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Antibiotics (Basel). 2022 Aug 3 11(8):1048.