TPDB

3D PDB MODEL

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TPDB ID TPDB20446

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GLVGKLVKGGLKLIGHVANG

FASTA

>TPDB20446|Antibacterial;Toxicity|length=20
GLVGKLVKGGLKLIGHVANG

Formula C88H156N26O22

Absent Amino Acids RDCEQMFPSTWY

Common Amino Acids G

Mass 1930.37

PI 10.84

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +3

Boman Index 1.90

Hydrophobicity 0.665

Aliphatic Index 146.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

0

R

1

N

0

D

0

C

0

E

0

Q

6

G

1

H

1

I

4

L

3

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

3

V

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 6 H: 1 I: 1 L: 4 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 3

Length

20

Formula

C88H156N26O22

Mass

1930.37

PI

10.84

Net Charge

+3

Boman Index

1.90

Hydrophobicity

0.665

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8-16 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 64-128 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 64-128 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64-128 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 64-128 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects. | Antibiotics (Basel) | 2022