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Peptide record

TPDB20442

Antibacterial Antiviral Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB20442
Antibacterial Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Antiviral, and Toxicity) peptide sequence curated from Peptipedia, AI4AVP, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
GLRRLLGRLLRRLGRLLLR
Physicochemical Analysis
C102H194N40O20
ANDCEQHIKMFPSTWYV
L
2300.92
13.18
7
0
9
+7
0.66
0.079
184.74
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
9
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 9 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
19
C102H194N40O20
2300.92
13.18
+7
0.66
0.079
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 4.4 uM) HSV-2MS in Vero cells (EC50 2.32 uM). E.coli (MIC > 100 uM).
Evidence 2 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 4.4 uM) HSV-2MS in Vero cells (EC50 2.32 uM). E.coli (MIC > 100 uM).
Evidence 3 Activity

Activity

50% Cell death
Toxicity
25.7 µM
Cytotoxic
50% Cell death | 25.7 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Antimicrob Agents Chemother | 2010
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.20086159]CEM-SS cells:50% Cell death at 25.7 µM.

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2010 Mar 54(3):1343-6.