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Peptide record

TPDB20438

Antibacterial Anticancer Toxicity modified_plain modified
15 amino acids
Basic Information
3D PDB MODEL
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TPDB20438
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 15-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
GLRKRLRKFXNKIKX
Physicochemical Analysis
C75H137N27O15
ADCEQHMPSTWYV
K
1657.08
12.72
7
0
4
+7
4.26
-1.207
78.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
2
L
4
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C75H137N27O15
1657.08
12.72
+7
4.26
-1.207
Evidence Records 9 records
Evidence 1 Activity

Activity

8% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
8% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity. | Biochem J | 2021
Evidence 2 Activity

Activity

10% Killing
Toxicity
40 µM
Cytotoxic
10% Killing | 40 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity. | Biochem J | 2021
Evidence 3 Activity

Activity

18% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
18% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity. | Biochem J | 2021
Evidence 4 Activity

Activity

25% Killing
Toxicity
40 µM
Cytotoxic
25% Killing | 40 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity. | Biochem J | 2021
Evidence 5 Activity

Activity

15% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
15% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity. | Biochem J | 2021
Evidence 6 Activity

Activity

30% Killing
Toxicity
40 µM
Cytotoxic
30% Killing | 40 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity. | Biochem J | 2021
Evidence 7 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: <10% Hemolysis =40 µM | Cytotoxicity: HEK293: <10% Killing=40 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem J. 2021 Jan 15 478(1):63-78.
Evidence 8 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: <10% Hemolysis =40 µM | Cytotoxicity: HEK293: 20% Killing=40 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem J. 2021 Jan 15 478(1):63-78.
Evidence 9 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: <10% Hemolysis =40 µM | Cytotoxicity: HEK293: <25% Killing=40 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem J. 2021 Jan 15 478(1):63-78.