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Peptide record

TPDB20437

Antibacterial Anticancer Cell-penetrating Peptides Hemolysis Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB20437
Antibacterial Anticancer Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia CPPsite3.0 PD_Hemolysis
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia, CPPsite3.0, and PD_Hemolysis, with an available 3D structural model.
Sequence
GLRKRLRKFRNKIKK
Physicochemical Analysis
C87H161N33O17
ADCEQHMPSTWYV
K
1941.45
12.89
9
0
4
+9
6.06
-1.767
78.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
4
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
2
L
5
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C87H161N33O17
1941.45
12.89
+9
6.06
-1.767
Evidence Records 4 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
10% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity. | Biochem J | 2021
Evidence 2 Activity

Activity

12% Killing
Toxicity
40 µM
Cytotoxic
12% Killing | 40 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity. | Biochem J | 2021
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: <10% Hemolysis =40 µM | Cytotoxicity: HEK293: <10% Killing=40 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem J. 2021 Jan 15 478(1):63-78.
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis