TPDB

3D PDB MODEL

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TPDB ID TPDB20417

Activity

Antibacterial Anticancer

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

Peptipedia CancerPPD 2.0 dbACP

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial and Anticancer) peptide sequence curated from Peptipedia, CancerPPD 2.0, and dbACP, with an available 3D structural model.

Sequence

GLMDMLKKVGKVALTVAKSALLP

FASTA

>TPDB20417|Antibacterial;Anticancer|length=23
GLMDMLKKVGKVALTVAKSALLP

Formula C108H195N27O28S2

Absent Amino Acids RNCEQHIFWY

Common Amino Acids L

Mass 2384.02

PI 10.55

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 13

Net Charge +3

Boman Index 2.37

Hydrophobicity 0.774

Aliphatic Index 135.65

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

3

A

0

R

0

N

1

D

0

C

0

E

0

Q

2

G

0

H

0

I

5

L

4

K

2

M

0

F

1

P

1

S

1

T

0

W

0

Y

3

V

Amino Acid Distribution

A: 3 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 5 K: 4 M: 2 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 3

Length

23

Formula

C108H195N27O28S2

Mass

2384.02

PI

10.55

Net Charge

+3

Boman Index

2.37

Hydrophobicity

0.774

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 31.3 µM

Target

Target Organism Staphylococcus aureus ATCC 12600

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ S. aureus ATCC 12600 (MIC 31.3 uM), Gram- E. coli ATCC 35218 (MIC 7.8 uM), K. pneumoniae ATCC 49472 (MIC 15.6 uM), and P. ae

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7.8 µM

Target

Target Organism Escherichia coli ATCC 35218

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ S. aureus ATCC 12600 (MIC 31.3 uM), Gram- E. coli ATCC 35218 (MIC 7.8 uM), K. pneumoniae ATCC 49472 (MIC 15.6 uM), and P. aeruginosa ATCC 9072 (MIC 15.6 uM). Also

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15.6 µM

Target

Target Organism Klebsiella pneumoniae ATCC 49472

Source & Reference

Database Source NA

Other

Evidence Text

against Gram+ S. aureus ATCC 12600 (MIC 31.3 uM), Gram- E. coli ATCC 35218 (MIC 7.8 uM), K. pneumoniae ATCC 49472 (MIC 15.6 uM), and P. aeruginosa ATCC 9072 (MIC 15.6 uM). Also showed cytotoxicity to cancer cells: lun

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15.6 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 9072

Source & Reference

Database Source NA

Other

Evidence Text

3 uM), Gram- E. coli ATCC 35218 (MIC 7.8 uM), K. pneumoniae ATCC 49472 (MIC 15.6 uM), and P. aeruginosa ATCC 9072 (MIC 15.6 uM). Also showed cytotoxicity to cancer cells: lung adenocarcinoma A549 (IC50 23 uM), breast