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Peptide record

TPDB20413

Antibacterial Anticancer Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB20413
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
GLPVCGETCVGGTCYTPGCTCSWPVCTRN
Physicochemical Analysis
C122H190N34O40S6
ADQHIKMF
C
2965.41
5.90
1
1
6
-0
0.90
0.228
43.45
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
248.36
14
Residue Composition
number
0
A
1
R
1
N
0
D
6
C
1
E
0
Q
5
G
0
H
0
I
1
L
0
K
0
M
0
F
3
P
1
S
5
T
1
W
1
Y
3
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 6 E: 1 Q: 0 G: 5 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 3 S: 1 T: 5 W: 1 Y: 1 V: 3
Chemical Descriptors
29
C122H190N34O40S6
2965.41
5.90
-0
0.90
0.228
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
6.9±0.3 µM
Hemolytic Cytotoxic
50% Hemolysis | 6.9±0.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting | Chembiochem | 2014
Evidence 2 Activity

Activity

50% Cell death
Toxicity
1.0±0.1 µM
Cytotoxic
50% Cell death | 1.0±0.1 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting | Chembiochem | 2014
Evidence 3 Activity

Activity

50% Cell death
Toxicity
6.7±0.6 µM
Cytotoxic
50% Cell death | 6.7±0.6 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting | Chembiochem | 2014
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis=6.9±0.3 µM | Cytotoxicity: HFF-1: CC50=6.7±0.6 µM PBMCs: CC50=1.0±0.1 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Chembiochem. 2014 Sep 5 15(13):1956-65.
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis