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Peptide record

TPDB20404

[T20K]kB1 Antibacterial Antiviral Cell-penetrating Peptides Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB20404
[T20K]kB1
Antibacterial Antiviral Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia AI4AVP CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 PerseuCPP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Antiviral, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia, AI4AVP, CellPPD, and other sources, with an available 3D structural model.
Sequence
GLPVCGETCVGGTCNTPGCKCSWPVCTRN
Physicochemical Analysis
C119H192N36O39S6
ADQHIMFY
C
2943.41
7.63
2
1
5
+1
3.11
0.041
43.45
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
199.60
13
Residue Composition
number
0
A
1
R
2
N
0
D
6
C
1
E
0
Q
5
G
0
H
0
I
1
L
1
K
0
M
0
F
3
P
1
S
4
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 5 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 3 S: 1 T: 4 W: 1 Y: 0 V: 3
Chemical Descriptors
29
C119H192N36O39S6
2943.41
7.63
+1
3.11
0.041
Free
L
Hydrophobic
Linear
Free
NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Mm96L Or Hff-1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
Cytoplasm and Endosomes
T20K* internalized is comparable with that of TAT* and to a greater extent than T16K* and V25K*.
Direct translocation and endocytosis
In vitro
CCTTCCCTTTTSSCCCCSCCCCCCCCSCC
Evidence 2 Activity

Activity

51% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
51% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities. | J Biol Chem | 2011
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2011 Oct 21 286(42):36932-47.
Evidence 4 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis
Additional Detail Fields 1 fields
CCTTCCCTTTTSSCCCCSCCCCCCCCSCC