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Peptide record

TPDB20401

Antibacterial Anticancer Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB20401
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GLPVCGETCVGGTCDTPGCTCSWPVCTRN
Physicochemical Analysis
C117H186N34O41S6
AQHIKMFY
C
2917.33
4.07
1
2
5
-1
3.07
0.152
43.45
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
201.38
13
Residue Composition
number
0
A
1
R
1
N
1
D
6
C
1
E
0
Q
5
G
0
H
0
I
1
L
0
K
0
M
0
F
3
P
1
S
5
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 5 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 3 S: 1 T: 5 W: 1 Y: 0 V: 3
Chemical Descriptors
29
C117H186N34O41S6
2917.33
4.07
-1
3.07
0.152
Evidence Records 4 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting | Chembiochem | 2014
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting | Chembiochem | 2014
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting | Chembiochem | 2014
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: Not active up to 50 µM | Cytotoxicity: HFF-1: Not active up to 60 µM PBMCs: Not active up to 60 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Chembiochem. 2014 Sep 5 15(13):1956-65.