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Peptide record

TPDB20388

Vigno 5 Antibacterial Anticancer Antifungal Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB20388
Vigno 5
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 dbACP Antifungipept ToxinPred 3.0
standard
No
A 29-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, dbACP, and other sources, with an available 3D structural model.
Sequence
GLPLCGETCVGGTCNTPGCSCGWPVCVRN
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C117H187N35O38S6
ADQHIKMFY
CG
2884.34
5.90
1
1
6
-0
0.29
0.317
56.90
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
2.04
12
Residue Composition
number
0
A
1
R
2
N
0
D
6
C
1
E
0
Q
6
G
0
H
0
I
2
L
0
K
0
M
0
F
3
P
1
S
3
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 6 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 3 S: 1 T: 3 W: 1 Y: 0 V: 3
Chemical Descriptors
29 reviewed residue count
C117H187N35O38S6 sequence-only estimate (linear, free termini)
2884.34 sequence-only estimate (linear, free termini)
5.90 sequence-only estimate (linear, free termini)
-0 sequence-only estimate (linear, free termini)
0.29 sequence-only estimate (linear, free termini)
0.317 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cyclic(C5-C19,C9-C21,C14-C21) Activity
Free Activity
Anticancer Activity
Viola ignobilis Activity
Evidence Records 3 records
Evidence 1 Activity

Activity

24% cell viability at 7.5 µM
Anticancer

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2015

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

50% Cell death
Toxicity
270 µM
Cytotoxic
50% Cell death | 270 | µM | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Viola plant cyclotide vigno 5 induces mitochondria-mediated apoptosis via cytochrome C release and caspases activation in cervical cancer cells. | Fitoterapia | 2016
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Fitoterapia. 2016 Mar 109:162-8