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Peptide record

TPDB20388

Vigno 5 Antibacterial Anticancer Antifungal Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB20388
Vigno 5
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 dbACP Antifungipept ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, dbACP, and other sources, with an available 3D structural model.
Sequence
GLPLCGETCVGGTCNTPGCSCGWPVCVRN
Physicochemical Analysis
C117H187N35O38S6
ADQHIKMFY
CG
2884.34
5.90
1
1
6
-0
1.43
0.317
56.90
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
203.69
12
Residue Composition
number
0
A
1
R
2
N
0
D
6
C
1
E
0
Q
6
G
0
H
0
I
2
L
0
K
0
M
0
F
3
P
1
S
3
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 6 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 3 S: 1 T: 3 W: 1 Y: 0 V: 3
Chemical Descriptors
29
C117H187N35O38S6
2884.34
5.90
-0
1.43
0.317
Free
L
Cyclic(C5-C19,C9-C21,C14-C21)
Free
Anticancer
Viola ignobilis
Evidence Records 3 records
Evidence 1 Activity

Activity

24% cell viability at 7.5 µM
Anticancer

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2015

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

50% Cell death
Toxicity
270 µM
Cytotoxic
50% Cell death | 270 | µM | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Viola plant cyclotide vigno 5 induces mitochondria-mediated apoptosis via cytochrome C release and caspases activation in cervical cancer cells. | Fitoterapia | 2016
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Fitoterapia. 2016 Mar 109:162-8