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Peptide record

TPDB20364

Antibacterial Toxicity modified_plain modified
13 amino acids
Basic Information
3D PDB MODEL
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TPDB20364
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 13-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
GLLSALXALGXLL
Physicochemical Analysis
C49H89N11O13
RNDCEQHIKMFPTWYV
L
1040.31
6.02
0
0
8
-0
-3.55
1.908
195.38
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
6
L
0
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 6 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C49H89N11O13
1040.31
6.02
-0
-3.55
1.908
Evidence Records 1 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
36 µM
Hemolytic Cytotoxic
50% Hemolysis | 36 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens. | Proc Natl Acad Sci U S A | 2019