TPDB

3D PDB MODEL

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TPDB ID TPDB20344

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GLLGKVLGVGKKVLCVVSGLC

FASTA

>TPDB20344|Antibacterial;Toxicity|length=21
GLLGKVLGVGKKVLCVVSGLC

Formula C92H168N24O23S2

Absent Amino Acids ARNDEQHIMFPTWY

Common Amino Acids GLV

Mass 2042.61

PI 9.80

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +3

Boman Index 0.22

Hydrophobicity 1.452

Aliphatic Index 161.90

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 6.12

Polar Residues 3

number

0

A

0

R

0

N

0

D

2

C

0

E

0

Q

5

G

0

H

0

I

5

L

3

K

0

M

0

F

0

P

1

S

0

T

0

W

0

Y

5

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 5 H: 0 I: 0 L: 5 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 5

Length

21

Formula

C92H168N24O23S2

Mass

2042.61

PI

9.80

Net Charge

+3

Boman Index

0.22

Hydrophobicity

1.452

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 4 ug/ml), S. enteritidis (MIC 16-32 ug/ml), and S. aureus ATCC 29213 (MIC 4 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16-32 µg/mL

Target

Target Organism S. enteritidis

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 4 ug/ml), S. enteritidis (MIC 16-32 ug/ml), and S. aureus ATCC 29213 (MIC 4 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 4 ug/ml), S. enteritidis (MIC 16-32 ug/ml), and S. aureus ATCC 29213 (MIC 4 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022