TPDB

3D PDB MODEL

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TPDB ID TPDB20343

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GLLGKVLGVGKKVLCGVTGRERCQ

FASTA

>TPDB20343|Antibacterial;Toxicity|length=24
GLLGKVLGVGKKVLCGVTGRERCQ

Formula C106H192N34O29S2

Absent Amino Acids ANDHIMFPSWY

Common Amino Acids G

Mass 2471.02

PI 10.32

Basic Residues 5

Acidic Residues 1

Hydrophobic Residues 8

Net Charge +4

Boman Index 4.95

Hydrophobicity 0.258

Aliphatic Index 113.33

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 5.06

Polar Residues 4

number

0

A

2

R

0

N

0

D

2

C

1

E

1

Q

6

G

0

H

0

I

4

L

3

K

0

M

0

F

0

P

0

S

1

T

0

W

0

Y

4

V

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 2 E: 1 Q: 1 G: 6 H: 0 I: 0 L: 4 K: 3 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 4

Length

24

Formula

C106H192N34O29S2

Mass

2471.02

PI

10.32

Net Charge

+4

Boman Index

4.95

Hydrophobicity

0.258

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 32 ug/ml), S. enteritidis (MIC 64 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µg/mL

Target

Target Organism S. enteritidis

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 32 ug/ml), S. enteritidis (MIC 64 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 32 ug/ml), S. enteritidis (MIC 64 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022