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Peptide record

TPDB20327

Antibacterial Antifungal Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB20327
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Sequence
GLNAAKKVFQGAHEAIKLINNHVQ
Physicochemical Analysis
C116H190N36O32
RDCMPSTWY
A
2601.01
10.32
5
1
11
+2
5.94
-0.204
105.83
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
4
A
0
R
3
N
0
D
0
C
1
E
2
Q
2
G
2
H
2
I
2
L
3
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 3 D: 0 C: 0 E: 1 Q: 2 G: 2 H: 2 I: 2 L: 2 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
24
C116H190N36O32
2601.01
10.32
+2
5.94
-0.204
Evidence Records 4 records
Evidence 1 Activity

Activity

18% Killing
Toxicity
64 µM
Cytotoxic
18% Killing | 64 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Improved Cell Selectivity of Pseudin-2 via Substitution in the Leucine-Zipper Motif: In Vitro and In Vivo Antifungal Activity. | Antibiotics (Basel) | 2020
Evidence 2 Activity

Activity

30% Killing
Toxicity
128 µM
Cytotoxic
30% Killing | 128 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Improved Cell Selectivity of Pseudin-2 via Substitution in the Leucine-Zipper Motif: In Vitro and In Vivo Antifungal Activity. | Antibiotics (Basel) | 2020
Evidence 3 Activity

Activity

78% Killing
Toxicity
256 µM
Cytotoxic
78% Killing | 256 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Improved Cell Selectivity of Pseudin-2 via Substitution in the Leucine-Zipper Motif: In Vitro and In Vivo Antifungal Activity. | Antibiotics (Basel) | 2020
Evidence 4 Activity

Activity

0% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
0% Hemolysis | 64 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Improved Cell Selectivity of Pseudin-2 via Substitution in the Leucine-Zipper Motif: In Vitro and In Vivo Antifungal Activity. | Antibiotics (Basel) | 2020