TPDB

3D PDB MODEL

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TPDB ID TPDB20296

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GLISGILGAGKKVLC

FASTA

>TPDB20296|Antibacterial;Toxicity|length=15
GLISGILGAGKKVLC

Formula C64H117N17O17S1

Absent Amino Acids RNDEQHMFPTWY

Common Amino Acids G

Mass 1428.80

PI 9.90

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +2

Boman Index -0.49

Hydrophobicity 1.247

Aliphatic Index 156.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

1

A

0

R

0

N

0

D

1

C

0

E

0

Q

4

G

0

H

2

I

3

L

2

K

0

M

0

F

0

P

1

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 4 H: 0 I: 2 L: 3 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

15

Formula

C64H117N17O17S1

Mass

1428.80

PI

9.90

Net Charge

+2

Boman Index

-0.49

Hydrophobicity

1.247

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64-128 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S.enteritidis (MIC 128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S.enteritidis (MIC 128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S.enteritidis (MIC 128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022