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Peptide record

TPDB20290

Antibacterial Anticancer Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB20290
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Sequence
GLHKVMREVLGYERNSYK
Physicochemical Analysis
C96H155N29O27S1
ADCQIFPTW
REGLKYV
2179.52
9.97
5
2
7
+2
6.08
-0.933
75.56
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
2980
136.73
4
Residue Composition
number
0
A
2
R
1
N
0
D
0
C
2
E
0
Q
2
G
1
H
0
I
2
L
2
K
1
M
0
F
0
P
1
S
0
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 2 H: 1 I: 0 L: 2 K: 2 M: 1 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 2 V: 2
Chemical Descriptors
18
C96H155N29O27S1
2179.52
9.97
+2
6.08
-0.933
Evidence Records 2 records
Evidence 1 Activity

Activity

6% Killing
Toxicity
128 µM
Cytotoxic
6% Killing | 128 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Central Role of the Copper-Binding Motif in the Complex Mechanism of Action of Ixosin: Enhancing Oxidative Damage and Promoting Synergy with Ixosin B. | ACS Infect Dis | 2016
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HEK-293: 6% Killing>128 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Libardo MD, Gorbatyuk VY, Angeles-Boza AM.