Back to search

Peptide record

TPDB20289

Antibacterial Anticancer Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB20289
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb
standard
No
A 12-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Sequence
GLHKVMREVLGY
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C63H104N18O16S1
ANDCQIFPSTW
GLV
1401.69
9.74
3
1
6
+1
0.83
0.058
113.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
1.06
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
1
E
0
Q
2
G
1
H
0
I
2
L
1
K
1
M
0
F
0
P
0
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 1 I: 0 L: 2 K: 1 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
12 reviewed residue count
C63H104N18O16S1 sequence-only estimate (linear, free termini)
1401.69 sequence-only estimate (linear, free termini)
9.74 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
0.83 sequence-only estimate (linear, free termini)
0.058 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

3% Cell death
Toxicity
128 µM
Cytotoxic
3% Cell death | 128 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Central Role of the Copper-Binding Motif in the Complex Mechanism of Action of Ixosin: Enhancing Oxidative Damage and Promoting Synergy with Ixosin B. | ACS Infect Dis | 2016
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HEK-293: 3% Killing>128 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Libardo MD, Gorbatyuk VY, Angeles-Boza AM.