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Peptide record

TPDB20268

Antibacterial Anticancer Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB20268
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
GLFDIVKKVLRLLK
Physicochemical Analysis
C79H140N20O17
ANCEQHMPSTWY
L
1642.10
10.83
4
1
8
+3
1.48
0.771
180.71
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
1
I
4
L
3
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 4 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
14
C79H140N20O17
1642.10
10.83
+3
1.48
0.771
Evidence Records 4 records
Evidence 1 Activity

Activity

EC50
Toxicity
8.9 µM
Cytotoxic
EC50 | 8.9 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
Simulated Molecular Evolution for Anticancer Peptide Design. | Angew Chem Int Ed Engl | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
25±1 µM
Hemolytic Cytotoxic
50% Hemolysis | 25±1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Simulated Molecular Evolution for Anticancer Peptide Design. | Angew Chem Int Ed Engl | 2019
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Angew Chem Int Ed Engl. 2019 Feb 4 58(6):1674-1679.
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis