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Peptide record

TPDB20254

Antibacterial Anticancer Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB20254
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GLEKRKRKFFNKIKFK
Physicochemical Analysis
C98H163N29O20
ADCQHMPSTWYV
K
2067.55
11.72
8
1
5
+7
5.75
-1.444
48.75
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
2
R
1
N
0
D
0
C
1
E
0
Q
1
G
0
H
1
I
1
L
6
K
0
M
3
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 6 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C98H163N29O20
2067.55
11.72
+7
5.75
-1.444
Evidence Records 3 records
Evidence 1 Activity

Activity

<10% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
<10% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity. | Biochem J | 2021
Evidence 2 Activity

Activity

20% Killing
Toxicity
40 µM
Cytotoxic
20% Killing | 40 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity. | Biochem J | 2021
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: <10% Hemolysis =40 µM | Cytotoxicity: HEK293: 20% Killing=40 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem J. 2021 Jan 15 478(1):63-78.