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Peptide record

TPDB20241

Antibacterial Anticancer Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB20241
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Sequence
GLAKVMRKVLGYLRNVYK
Physicochemical Analysis
C97H166N28O22S1
DCEQHIFPSTW
LKV
2108.62
10.95
5
0
10
+5
1.28
0.006
118.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
2980
141.32
3
Residue Composition
number
1
A
2
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
3
L
3
K
1
M
0
F
0
P
0
S
0
T
0
W
2
Y
3
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 3 K: 3 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 3
Chemical Descriptors
18
C97H166N28O22S1
2108.62
10.95
+5
1.28
0.006
Evidence Records 2 records
Evidence 1 Activity

Activity

23% Killing
Toxicity
4 µM
Cytotoxic
23% Killing | 4 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Central Role of the Copper-Binding Motif in the Complex Mechanism of Action of Ixosin: Enhancing Oxidative Damage and Promoting Synergy with Ixosin B. | ACS Infect Dis | 2016
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HEK-293: 23% Killing=2-4 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Libardo MD, Gorbatyuk VY, Angeles-Boza AM.