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Peptide record

TPDB20240

Antibacterial Anticancer Antifungal Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB20240
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb
standard
No
A 23-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Sequence
GLAKVMREVLGYERNSYKKFFLR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C129H206N36O32S1
DCQHIPTW
RLK
2805.34
10.55
6
2
11
+4
2.20
-0.470
80.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
2980
1.06
4
Residue Composition
number
1
A
3
R
1
N
0
D
0
C
2
E
0
Q
2
G
0
H
0
I
3
L
3
K
1
M
2
F
0
P
1
S
0
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 2 H: 0 I: 0 L: 3 K: 3 M: 1 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 2 V: 2
Chemical Descriptors
23 reviewed residue count
C129H206N36O32S1 sequence-only estimate (linear, free termini)
2805.34 sequence-only estimate (linear, free termini)
10.55 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
2.20 sequence-only estimate (linear, free termini)
-0.470 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Central Role of the Copper-Binding Motif in the Complex Mechanism of Action of Ixosin: Enhancing Oxidative Damage and Promoting Synergy with Ixosin B. | ACS Infect Dis | 2016
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HEK-293: Not active up to 16 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Libardo MD, Gorbatyuk VY, Angeles-Boza AM.