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Peptide record

TPDB20205

Antibacterial Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB20205
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 22-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GKCIAKAIFKGAKKFLKKLVNP
Physicochemical Analysis
C114H196N30O24S1
RDEQHMSTWY
K
2403.06
10.92
7
0
10
+7
3.14
0.050
97.73
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
3
A
0
R
1
N
0
D
1
C
0
E
0
Q
2
G
0
H
2
I
2
L
7
K
0
M
2
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 2 K: 7 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
22
C114H196N30O24S1
2403.06
10.92
+7
3.14
0.050
Evidence Records 1 records
Evidence 1 Activity

Activity

16.7 ± 5.2% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
16.7 ± 5.2% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Strategic modification of low-activity natural antimicrobial peptides confers antibacterial potential in vitro and in vivo. | Eur J Med Chem | 2023