TPDB

3D PDB MODEL

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TPDB ID TPDB20171

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GIYTGRLLPVYIPQPRPPHPRLRR

FASTA

>TPDB20171|Antibacterial;Toxicity|length=24
GIYTGRLLPVYIPQPRPPHPRLRR

Formula C132H214N42O29

Absent Amino Acids ANDCEKMFSW

Common Amino Acids P

Mass 2853.42

PI 12.23

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +5

Boman Index 4.34

Hydrophobicity -0.763

Aliphatic Index 93.33

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 104.44

Polar Residues 4

number

0

A

5

R

0

N

0

D

0

C

0

E

1

Q

2

G

1

H

2

I

3

L

0

K

0

M

0

F

6

P

0

S

1

T

0

W

2

Y

1

V

Amino Acid Distribution

A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 1 I: 2 L: 3 K: 0 M: 0 F: 0 P: 6 S: 0 T: 1 W: 0 Y: 2 V: 1

Length

24

Formula

C132H214N42O29

Mass

2853.42

PI

12.23

Net Charge

+5

Boman Index

4.34

Hydrophobicity

-0.763

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4-8 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 4-8 ug/ml), S. enteritidis (MIC 16-32 ug/ml), and S.aureus ATCC 29213 (MIC>128 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16-32 µg/mL

Target

Target Organism S. enteritidis

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 4-8 ug/ml), S. enteritidis (MIC 16-32 ug/ml), and S.aureus ATCC 29213 (MIC>128 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 4-8 ug/ml), S. enteritidis (MIC 16-32 ug/ml), and S.aureus ATCC 29213 (MIC>128 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects. | Antibiotics (Basel) | 2022