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Peptide record

TPDB20149

Antibacterial Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB20149
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 16-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GIRRGIIKIIKRIKRI
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C88H169N31O17
ANDCEQHLMFPSTWYV
I
1933.51
12.88
7
0
7
+7
2.50
0.062
170.62
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
7
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 7 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16 reviewed residue count
C88H169N31O17 sequence-only estimate (linear, free termini)
1933.51 sequence-only estimate (linear, free termini)
12.88 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
2.50 sequence-only estimate (linear, free termini)
0.062 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

45% Killing
Toxicity
128 µM
Cytotoxic
45% Killing | 128 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
De Novo Designed Hexadecapeptides Synergize Glycopeptide Antibiotics Vancomycin and Teicoplanin against Pathogenic Klebsiella pneumoniae via Disruption of Cell Permeability and Potential | ACS Appl Bio Mater | 2020