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Peptide record

TPDB20147

Antibacterial Anticancer Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB20147
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia SATPdb HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia, SATPdb, HemoPI, and other sources, with an available 3D structural model.
Sequence
GIRKWFKKAAHVGKEVGKVALNACL
Physicochemical Analysis
C125H207N37O29S1
DQMPSTY
K
2724.31
10.70
7
1
12
+5
4.07
0.036
97.60
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
201.89
2
Residue Composition
number
4
A
1
R
1
N
0
D
1
C
1
E
0
Q
3
G
1
H
1
I
2
L
5
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 0 C: 1 E: 1 Q: 0 G: 3 H: 1 I: 1 L: 2 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
25
C125H207N37O29S1
2724.31
10.70
+5
4.07
0.036
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 2 Activity

Activity

>10% Killing
Toxicity
5 µM
Cytotoxic
>10% Killing | 5 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 3 Activity

Activity

>10% Killing
Toxicity
25 µM
Cytotoxic
>10% Killing | 25 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis>256 µg/ml | Cytotoxicity: Zebrafish embryos: >10% Killing=5 µg/ml (4, 52hpf embryo) >10% Killing=25 µg/ml (28hpf embryo)

Target

erythrocytes

Source & Reference

NA
DRAMP
Dis Model Mech. 2011 Sep 4(5):622-33.
Evidence 5 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis