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Peptide record

TPDB20143

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB20143
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia Antifungipept CAFPdb dbAMP 3.0 i2APP AI4AVP DRAMP DRAVP 2.0 APD_complete Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.
Sequence
GIPCGESCVWIPCISAAIGCSCKSKVCYRN
Physicochemical Analysis
C133H215N37O39S6
DQHLMFT
C
3148.75
8.02
3
1
10
+2
1.01
0.530
78.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
233.90
12
Residue Composition
number
2
A
1
R
1
N
0
D
6
C
1
E
0
Q
3
G
0
H
4
I
0
L
2
K
0
M
0
F
2
P
4
S
0
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 4 L: 0 K: 2 M: 0 F: 0 P: 2 S: 4 T: 0 W: 1 Y: 1 V: 2
Chemical Descriptors
30
C133H215N37O39S6
3148.75
8.02
+2
1.01
0.530
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

F. oxysporum

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
hus contortus or Trichostrongylus colubriformis). Fungi: Also, active against plant fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak e
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µM

Target

B. cinerea

Source & Reference

DRAMP

Other

us colubriformis). Fungi: Also, active against plant fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak et al. 2018 ). Virus: It
Evidence 3 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

C. utrechtense

Source & Reference

DRAMP

Other

i: Also, active against plant fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak et al. 2018 ). Virus: It inhibited HIV-1 infection in
Evidence 4 Activity

Activity

MIC
Antibacterial
3 µM

Target

A. alternatam

Source & Reference

DRAMP

Other

fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak et al. 2018 ). Virus: It inhibited HIV-1 infection in cultured human T-lymphobla
Evidence 5 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

F. oxysporum

Source & Reference

DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms.
hus contortus or Trichostrongylus colubriformis). Fungi: Also, active against plant fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak e
Evidence 6 Activity

Activity

MIC
Antifungal
3 µM

Target

B. cinerea

Source & Reference

DRAMP CAFPdb Antifungipept

Other

us colubriformis). Fungi: Also, active against plant fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak et al. 2018 ). Virus: It
Evidence 7 Activity

Activity

MIC
Antifungal
6.25 µM

Target

C. utrechtense

Source & Reference

DRAMP CAFPdb Antifungipept

Other

i: Also, active against plant fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak et al. 2018 ). Virus: It inhibited HIV-1 infection in
Evidence 8 Activity

Activity

MIC
Antifungal
3 µM

Target

A. alternatam

Source & Reference

DRAMP CAFPdb Antifungipept

Other

fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak et al. 2018 ). Virus: It inhibited HIV-1 infection in cultured human T-lymphobla
Evidence 9 Activity

Activity

MIC
Antiparasitic
12.5-25 µM

Target

F. oxysporum

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class. DRAMP antiparasitic activity supported by activity records against parasitic targets.
hus contortus or Trichostrongylus colubriformis). Fungi: Also, active against plant fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak e
Evidence 10 Activity

Activity

MIC
Antiparasitic
3 µM

Target

B. cinerea

Source & Reference

dbAMP 3.0 DRAMP

Other

us colubriformis). Fungi: Also, active against plant fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak et al. 2018 ). Virus: It
Evidence 11 Activity

Activity

MIC
Antiparasitic
6.25 µM

Target

C. utrechtense

Source & Reference

dbAMP 3.0 DRAMP

Other

i: Also, active against plant fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak et al. 2018 ). Virus: It inhibited HIV-1 infection in
Evidence 12 Activity

Activity

MIC
Antiparasitic
3 µM

Target

A. alternatam

Source & Reference

dbAMP 3.0 DRAMP

Other

fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak et al. 2018 ). Virus: It inhibited HIV-1 infection in cultured human T-lymphobla
Evidence 13 Activity

Activity

MIC
Antiviral
12.5-25 µM

Target

F. oxysporum

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class. DRAMP antiviral activity supported by activity records against viral targets.
hus contortus or Trichostrongylus colubriformis). Fungi: Also, active against plant fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak e
Evidence 14 Activity

Activity

MIC
Antiviral
3 µM

Target

B. cinerea

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

us colubriformis). Fungi: Also, active against plant fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak et al. 2018 ). Virus: It
Evidence 15 Activity

Activity

MIC
Antiviral
6.25 µM

Target

C. utrechtense

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

i: Also, active against plant fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak et al. 2018 ). Virus: It inhibited HIV-1 infection in
Evidence 16 Activity

Activity

MIC
Antiviral
3 µM

Target

A. alternatam

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

fungi F. oxysporum (MIC 12.5-25 uM), B. cinerea (MIC 3 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 3 uM) ( Slazak et al. 2018 ). Virus: It inhibited HIV-1 infection in cultured human T-lymphobla
Evidence 17 Activity

Activity

% Hemolysis
Hemolysis
50 75 %
[Ref:16872274] It has 50% hemolytic activity at 1.0 µM and 75% hemolytic activity at 1.5 µM against human type A red blood cells

Target

human type A red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochem J. 2006 Nov 15 400(1):1-12.##Biopolymers. 2008 90(1):51-60.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 18 Activity

Activity

50% Hemolysis
Toxicity
11 µM
Hemolytic Cytotoxic
50% Hemolysis | 11 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability. | Biochem J | 2006
Evidence 19 Activity

Activity

IC50
Toxicity
6.4 µM
Cytotoxic
IC50 | 6.4 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Cyclotides as natural anti-HIV agents | Biopolymers | 2008
Evidence 20 Activity

Activity

IC50
Toxicity
6400 nM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref:16872274] It has 50% hemolytic activity at 1.0 µM and 75% hemolytic activity at 1.5 µM against human type A red blood cells | Cytotoxicity: [Ref.18008336]CEM-SS cells:IC50=6400 nM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem J. 2006 Nov 15 400(1):1-12.##Biopolymers. 2008 90(1):51-60.
Evidence 21 Hemolysis

Activity

50 75 %
% Hemolysis
[Ref:16872274] It has 50% hemolytic activity at 1.0 µM and 75% hemolytic activity at 1.5 µM against human type A red blood cells
Hemolysis

Target

human type A red blood cells

Source & Reference

APD_complete PD_Hemolysis
Biochem J. 2006 Nov 15 400(1):1-12.##Biopolymers. 2008 90(1):51-60.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.