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Peptide record

TPDB20137

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB20137
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept dbAMP 3.0 AI4AVP AVPpred-BWR DRAMP DRAVP 2.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiCP 2.0, iACP-DRLF, and other sources, with an available 3D structural model.
Sequence
GIPCAESCVWIPCTVTALVGCSCSDKVCYN
Physicochemical Analysis
C132H209N33O42S6
RQHMF
C
3122.67
4.07
1
2
11
-1
0.78
0.793
84.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
235.86
13
Residue Composition
number
2
A
0
R
1
N
1
D
6
C
1
E
0
Q
2
G
0
H
2
I
1
L
1
K
0
M
0
F
2
P
3
S
2
T
1
W
1
Y
4
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 1 M: 0 F: 0 P: 2 S: 3 T: 2 W: 1 Y: 1 V: 4
Chemical Descriptors
30
C132H209N33O42S6
3122.67
4.07
-1
0.78
0.793
Evidence Records 9 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

DRAMP

Other

It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 40 nM) and cytotoxicity (TC50 1760 nM), therapeutic index (44) (Ireland et al., 2008) .
Evidence 2 Activity

Activity

Antifungal

Source & Reference

DRAMP Antifungipept

Other

It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 40 nM) and cytotoxicity (TC50 1760 nM), therapeutic index (44) (Ireland et al., 2008) .
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 40 nM) and cytotoxicity (TC50 1760 nM), therapeutic index (44) (Ireland et al., 2008) .
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 40 nM) and cytotoxicity (TC50 1760 nM), therapeutic index (44) (Ireland et al., 2008) .
Evidence 5 Activity

Activity

HD50
Hemolysis
8.7 µM
[Ref:18081258] HD50=8.7 µM against human type A red blood cells.

Target

human type A red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Nat Prod. 2008 Jan 71(1):47-52.##Biopolymers. 2008 90(1):51-60.##Chembiochem. 2008 Aug 11 9(12):1939-45. doi: 10.1002/cbic.200800174.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
8.7 µM
Hemolytic Cytotoxic
50% Hemolysis | 8.7 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis | J Nat Prod | 2008
Evidence 7 Activity

Activity

IC50
Toxicity
1.8 µM
Cytotoxic
IC50 | 1.8 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis | J Nat Prod | 2008
Evidence 8 Activity

Activity

HD50
Toxicity
8.7 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref:18081258] HD50=8.7 µM against human type A red blood cells. | Cytotoxicity: [Ref.18008336]CEM-SS cells:IC50=1760 nM.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Nat Prod. 2008 Jan 71(1):47-52.##Biopolymers. 2008 90(1):51-60.##Chembiochem. 2008 Aug 11 9(12):1939-45. doi: 10.1002/cbic.200800174.
Evidence 9 Hemolysis

Activity

8.7 µM
HD50
[Ref:18081258] HD50=8.7 µM against human type A red blood cells.
Hemolysis

Target

human type A red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Nat Prod. 2008 Jan 71(1):47-52.##Biopolymers. 2008 90(1):51-60.##Chembiochem. 2008 Aug 11 9(12):1939-45. doi: 10.1002/cbic.200800174.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.