TPDB

3D PDB MODEL

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TPDB ID TPDB20136

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept AI4AVP dbAMP 3.0 DRAMP APD_complete APD_hemolytic Hemolytic2 ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiCP 2.0, iACP-DRLF, and other sources, with an available 3D structural model.

Sequence

GIPCAESCVWIPCTVTALLGCSCSNNVCYN

FASTA

>TPDB20136|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=30
GIPCAESCVWIPCTVTALLGCSCSNNVCYN

Formula C131H206N34O42S6

Absent Amino Acids RDQHKMF

Common Amino Acids C

Mass 3121.64

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 11

Net Charge -1

Boman Index -1.23

Hydrophobicity 0.793

Aliphatic Index 87.67

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 7365

Absorbance 280nm 235.93

Polar Residues 15

number

2

A

0

R

3

N

0

D

6

C

1

E

0

Q

2

G

0

H

2

I

2

L

0

K

0

M

0

F

2

P

3

S

2

T

1

W

1

Y

3

V

Amino Acid Distribution

A: 2 R: 0 N: 3 D: 0 C: 6 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 2 K: 0 M: 0 F: 0 P: 2 S: 3 T: 2 W: 1 Y: 1 V: 3

Length

30

Formula

C131H206N34O42S6

Mass

3121.64

PI

3.29

Net Charge

-1

Boman Index

-1.23

Hydrophobicity

0.793

Evidence 1 Activity

Activity

Activity Endpoint HD50

Detail Source Activity Hemolysis

Activity Measurement 5.5 µM

Hemolysis Raw

[Ref.16441062] HD50=5.5 µM against human type A red blood cells.

Target

RBC Target human type A red blood cells

Source & Reference

Database Source APD_complete APD_hemolytic

Source DRAMP4

Reference

J Mol Biol. 1999 Dec 17 294(5):1327-1336.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint HD50

Detail Source Activity Toxicity

Activity Measurement 5.5 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.16441062] HD50=5.5 µM against human type A red blood cells.

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

J Mol Biol. 1999 Dec 17 294(5):1327-1336.

Evidence 3 Hemolysis

Activity

Activity Measurement 5.5 µM

Activity Endpoint HD50

Hemolysis Raw

[Ref.16441062] HD50=5.5 µM against human type A red blood cells.

Detail Source Activity Hemolysis

Target

RBC Target human type A red blood cells

Source & Reference

source APD_complete APD_hemolytic

Reference

J Mol Biol. 1999 Dec 17 294(5):1327-1336.

Source DRAMP4

Database Source APD_complete APD_hemolytic