TPDB

3D PDB MODEL

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TPDB ID TPDB20117

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GILSGLLGAGKKLACGLIGLC

FASTA

>TPDB20117|Antibacterial;Toxicity|length=21
GILSGLLGAGKKLACGLIGLC

Formula C87H157N23O23S2

Absent Amino Acids RNDEQHMFPTWYV

Common Amino Acids GL

Mass 1957.46

PI 9.11

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +2

Boman Index -2.63

Hydrophobicity 1.400

Aliphatic Index 158.10

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 6.39

Polar Residues 3

number

2

A

0

R

0

N

0

D

2

C

0

E

0

Q

6

G

0

H

2

I

6

L

2

K

0

M

0

F

0

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 6 H: 0 I: 2 L: 6 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

21

Formula

C87H157N23O23S2

Mass

1957.46

PI

9.11

Net Charge

+2

Boman Index

-2.63

Hydrophobicity

1.400

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8 ug/ml), S. enteritidis (MIC 32-64 ug/ml), and S. aureus ATCC 29213 (MIC 8-16 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32-64 µg/mL

Target

Target Organism S. enteritidis

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8 ug/ml), S. enteritidis (MIC 32-64 ug/ml), and S. aureus ATCC 29213 (MIC 8-16 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8-16 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8 ug/ml), S. enteritidis (MIC 32-64 ug/ml), and S. aureus ATCC 29213 (MIC 8-16 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022