TPDB

3D PDB MODEL

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TPDB ID TPDB20115

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GILSGLLGAGKKIVCGLSGLC

FASTA

>TPDB20115|Antibacterial;Toxicity|length=21
GILSGLLGAGKKIVCGLSGLC

Formula C86H155N23O24S2

Absent Amino Acids RNDEQHMFPTWY

Common Amino Acids G

Mass 1959.44

PI 9.11

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +2

Boman Index -1.70

Hydrophobicity 1.295

Aliphatic Index 148.57

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 6.38

Polar Residues 4

number

1

A

0

R

0

N

0

D

2

C

0

E

0

Q

6

G

0

H

2

I

5

L

2

K

0

M

0

F

0

P

2

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 6 H: 0 I: 2 L: 5 K: 2 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1

Length

21

Formula

C86H155N23O24S2

Mass

1959.44

PI

9.11

Net Charge

+2

Boman Index

-1.70

Hydrophobicity

1.295

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8-16 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S. enteritidis (MIC 64-128 ug/ml), and S. aureus ATCC 29213 (MIC 8-16 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64-128 µg/mL

Target

Target Organism S. enteritidis

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S. enteritidis (MIC 64-128 ug/ml), and S. aureus ATCC 29213 (MIC 8-16 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8-16 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

ctive against E. coli ATCC 25922 (MIC 8-16 ug/ml), S. enteritidis (MIC 64-128 ug/ml), and S. aureus ATCC 29213 (MIC 8-16 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022