TPDB

3D PDB MODEL

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TPDB ID TPDB20113

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 19-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GILRSLGWIQMPRSRRRHR

FASTA

>TPDB20113|Antibacterial;Toxicity|length=19
GILRSLGWIQMPRSRRRHR

Formula C102H175N41O23S1

Absent Amino Acids ANDCEKFTYV

Common Amino Acids R

Mass 2375.83

PI 13.10

Basic Residues 7

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +6

Boman Index 3.31

Hydrophobicity -1.058

Aliphatic Index 82.11

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 231.50

Polar Residues 3

number

0

A

6

R

0

N

0

D

0

C

0

E

1

Q

2

G

1

H

2

I

2

L

0

K

1

M

0

F

1

P

2

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 1 I: 2 L: 2 K: 0 M: 1 F: 0 P: 1 S: 2 T: 0 W: 1 Y: 0 V: 0

Length

19

Formula

C102H175N41O23S1

Mass

2375.83

PI

13.10

Net Charge

+6

Boman Index

3.31

Hydrophobicity

-1.058

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16-32 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 16-32 ug/ml), S.enteritidis (MIC 128 ug/ml), and S.aureus ATCC 29213 (MIC>128 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 16-32 ug/ml), S.enteritidis (MIC 128 ug/ml), and S.aureus ATCC 29213 (MIC>128 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 16-32 ug/ml), S.enteritidis (MIC 128 ug/ml), and S.aureus ATCC 29213 (MIC>128 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects. | Antibiotics (Basel) | 2022