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Peptide record

TPDB20100

Antibacterial Anticancer Toxicity modified_plain modified
23 amino acids
Basic Information
3D PDB MODEL
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TPDB20100
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 23-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
GIKXWLHSAKKFGXKFVKKIXNS
Physicochemical Analysis
C111H178N30O24
RDCEQMPTY
K
2316.82
11.21
7
0
8
+6
2.21
-0.391
67.83
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
237.39
3
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
1
H
2
I
1
L
6
K
0
M
2
F
0
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 2 L: 1 K: 6 M: 0 F: 2 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
23
C111H178N30O24
2316.82
11.21
+6
2.21
-0.391
Evidence Records 4 records
Evidence 1 Activity

Activity

EC50
Toxicity
25.9±0.6 µM
Cytotoxic
EC50 | 25.9±0.6 | µM | target cell: Human kidney-derived GM cells

Target

Human kidney-derived GM cells

Source & Reference

NA
DBAASP
Endowment of pH responsivity to anticancer peptides by introducing 2,3-diaminopropionic acid residues. | Chembiochem | 2019
Evidence 2 Activity

Activity

EC50
Toxicity
50.3±0.9 µM
Cytotoxic
EC50 | 50.3±0.9 | µM | target cell: Human kidney-derived GM cells

Target

Human kidney-derived GM cells

Source & Reference

NA
DBAASP
Endowment of pH responsivity to anticancer peptides by introducing 2,3-diaminopropionic acid residues. | Chembiochem | 2019
Evidence 3 Activity

Activity

EC50
Toxicity
27.2±3.1 µM
Cytotoxic
EC50 | 27.2±3.1 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Endowment of pH responsivity to anticancer peptides by introducing 2,3-diaminopropionic acid residues. | Chembiochem | 2019
Evidence 4 Activity

Activity

EC50
Toxicity
25.9
Hemolytic Cytotoxic
Hemolytic_activity: Human kidney-derived GM cells: EC50=25.9±0.6 µM(pH=6) EC50=50.3±0.9 µM(pH=7.4) | Cytotoxicity: HEK293: EC50=27.2±3.1 µM(pH=7.4)

Target

erythrocytes

Source & Reference

NA
DRAMP
Chembiochem. 2019 Aug 16 20(16):2109-2117.