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Peptide record

TPDB20088

Antibacterial Anticancer Toxicity modified_plain modified
23 amino acids
Basic Information
3D PDB MODEL
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TPDB20088
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 23-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
GIKKWLHSAKKFGKKFVKKIXNS
Physicochemical Analysis
C123H202N34O26
RDCEQMPTY
K
2573.17
11.36
9
0
8
+8
4.19
-0.730
67.83
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
213.74
3
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
1
H
2
I
1
L
8
K
0
M
2
F
0
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 2 L: 1 K: 8 M: 0 F: 2 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
23
C123H202N34O26
2573.17
11.36
+8
4.19
-0.730
Evidence Records 4 records
Evidence 1 Activity

Activity

EC50
Toxicity
7.6±2.1 µM
Cytotoxic
EC50 | 7.6±2.1 | µM | target cell: Human kidney-derived GM cells

Target

Human kidney-derived GM cells

Source & Reference

NA
DBAASP
Endowment of pH responsivity to anticancer peptides by introducing 2,3-diaminopropionic acid residues. | Chembiochem | 2019
Evidence 2 Activity

Activity

EC50
Toxicity
25.6±4.5 µM
Cytotoxic
EC50 | 25.6±4.5 | µM | target cell: Human kidney-derived GM cells

Target

Human kidney-derived GM cells

Source & Reference

NA
DBAASP
Endowment of pH responsivity to anticancer peptides by introducing 2,3-diaminopropionic acid residues. | Chembiochem | 2019
Evidence 3 Activity

Activity

EC50
Toxicity
15.7±1.8 µM
Cytotoxic
EC50 | 15.7±1.8 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Endowment of pH responsivity to anticancer peptides by introducing 2,3-diaminopropionic acid residues. | Chembiochem | 2019
Evidence 4 Activity

Activity

EC50
Toxicity
7.6
Hemolytic Cytotoxic
Hemolytic_activity: Human kidney-derived GM cells: EC50=7.6±2.1 µM(pH=6) EC50=25.6±4.5 µM(pH=7.4) | Cytotoxicity: HEK293: EC50=15.7±1.8 µM(pH=7.4)

Target

erythrocytes

Source & Reference

NA
DRAMP
Chembiochem. 2019 Aug 16 20(16):2109-2117.