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Peptide record

TPDB20078

Antibacterial Antiviral Toxicity modified_plain modified
20 amino acids
Basic Information
3D PDB MODEL
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TPDB20078
Antibacterial Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia dbAMP 3.0 DRAVP 2.0
modified_plain
Yes
A 20-aa modified multi-activity (Antibacterial, Antiviral, and Toxicity) peptide sequence curated from Peptipedia, dbAMP 3.0, and DRAVP 2.0, with an available 3D structural model.
Modified, details unspecified
Sequence
GIKEXKRIVQRIKDFLRNLV
Physicochemical Analysis
C105H185N33O26
ACHMPSTWY
RIK
2325.83
11.46
6
2
8
+4
6.62
-0.365
126.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
1
E
1
Q
1
G
0
H
3
I
2
L
3
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 3 L: 2 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
20
C105H185N33O26
2325.83
11.46
+4
6.62
-0.365
Evidence Records 2 records
Evidence 1 Activity

Activity

50% cell death
Toxicity
7.3 µM
Cytotoxic
50% cell death | 7.3 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins | Antimicrob Agents Chemother | 2008
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.18591279]CEM-SS cells:TC50=7.3 µM.(TC50:the concentration that reduced cell viability by 50%)

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2008 Sep 52(9):3438-40.