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Peptide record

TPDB20077

Antibacterial Antiviral Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB20077
Antibacterial Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Antiviral, and Toxicity) peptide sequence curated from Peptipedia, AI4AVP, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
GIKEWKRIVQRIKDFLRNLV
Physicochemical Analysis
C116H195N35O27
ACHMPSTY
RIK
2512.04
11.46
6
2
9
+4
4.77
-0.410
126.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
218.95
2
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
1
E
1
Q
1
G
0
H
3
I
2
L
3
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 3 L: 2 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
20
C116H195N35O27
2512.04
11.46
+4
4.77
-0.410
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 7.4 uM).
Evidence 2 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 7.4 uM).
Evidence 3 Activity

Activity

50% cell death
Toxicity
23.6 µM
Cytotoxic
50% cell death | 23.6 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins | Antimicrob Agents Chemother | 2008
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.18591279]CEM-SS cells:TC50=23.6 µM.(TC50:the concentration that reduced cell viability by 50%)

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2008 Sep 52(9):3438-40.