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Peptide record

TPDB20076

Antibacterial Anticancer Antiviral Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB20076
Antibacterial Anticancer Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from Peptipedia, AI4AVP, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
GIKEFKRIVQRIKDFLRNLV
Physicochemical Analysis
C114H194N34O27
ACHMPSTWY
RIK
2473.01
11.46
6
2
9
+4
5.49
-0.225
126.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
1
E
1
Q
1
G
0
H
3
I
2
L
3
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 3 L: 2 K: 3 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
20
C114H194N34O27
2473.01
11.46
+4
5.49
-0.225
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

E. faecium V284-17

Source & Reference

NA

Other

It inhibits HIV-1. Active against E. faecium V284-17 (MIC 2 uM), S. aureus USA300 (MIC 2-4 uM), K-pneumoniae E406-17 (MIC>32 uM). A. baumannii B28-16 (MI
Evidence 2 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Staphylococcus aureus USA300

Source & Reference

NA

Other

It inhibits HIV-1. Active against E. faecium V284-17 (MIC 2 uM), S. aureus USA300 (MIC 2-4 uM), K-pneumoniae E406-17 (MIC>32 uM). A. baumannii B28-16 (MIC 8 uM), P-aeruginosa E411-17 (
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

A. baumannii B28-16

Source & Reference

NA

Other

cium V284-17 (MIC 2 uM), S. aureus USA300 (MIC 2-4 uM), K-pneumoniae E406-17 (MIC>32 uM). A. baumannii B28-16 (MIC 8 uM), P-aeruginosa E411-17 (MIC > 32 uM), and E. coli E423-17 (MIC 32 uM). It also dispersed p
Evidence 4 Activity

Activity

MIC
Antibacterial
32 µM

Target

Escherichia coli E423-17

Source & Reference

NA

Other

6-17 (MIC>32 uM). A. baumannii B28-16 (MIC 8 uM), P-aeruginosa E411-17 (MIC > 32 uM), and E. coli E423-17 (MIC 32 uM). It also dispersed preformed biofilms at 64 uM ( Zhang et al., 2021 ). Virus: inhibited H
Evidence 5 Activity

Activity

MIC
Antiviral
2 µM

Target

E. faecium V284-17

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
It inhibits HIV-1. Active against E. faecium V284-17 (MIC 2 uM), S. aureus USA300 (MIC 2-4 uM), K-pneumoniae E406-17 (MIC>32 uM). A. baumannii B28-16 (MI
Evidence 6 Activity

Activity

MIC
Antiviral
2-4 µM

Target

Staphylococcus aureus USA300

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

It inhibits HIV-1. Active against E. faecium V284-17 (MIC 2 uM), S. aureus USA300 (MIC 2-4 uM), K-pneumoniae E406-17 (MIC>32 uM). A. baumannii B28-16 (MIC 8 uM), P-aeruginosa E411-17 (
Evidence 7 Activity

Activity

MIC
Antiviral
8 µM

Target

A. baumannii B28-16

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

cium V284-17 (MIC 2 uM), S. aureus USA300 (MIC 2-4 uM), K-pneumoniae E406-17 (MIC>32 uM). A. baumannii B28-16 (MIC 8 uM), P-aeruginosa E411-17 (MIC > 32 uM), and E. coli E423-17 (MIC 32 uM). It also dispersed p
Evidence 8 Activity

Activity

MIC
Antiviral
32 µM

Target

Escherichia coli E423-17

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

6-17 (MIC>32 uM). A. baumannii B28-16 (MIC 8 uM), P-aeruginosa E411-17 (MIC > 32 uM), and E. coli E423-17 (MIC 32 uM). It also dispersed preformed biofilms at 64 uM ( Zhang et al., 2021 ). Virus: inhibited H
Evidence 9 Activity

Activity

50% cell death
Toxicity
22.7 µM
Cytotoxic
50% cell death | 22.7 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins | Antimicrob Agents Chemother | 2008
Evidence 10 Activity

Activity

50% Cytotoxicity
Toxicity
>40 µM
Cytotoxic
50% Cytotoxicity | >40 | µM | target cell: Human primary macrophages

Target

Human primary macrophages

Source & Reference

NA
DBAASP
Engineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection. | iScience | 2020
Evidence 11 Activity

Activity

30% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
30% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure and Activity of a Selective Antibiofilm Peptide SK-24 Derived from the NMR Structure of Human Cathelicidin LL-37. | Pharmaceuticals (Basel) | 2021
Evidence 12 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.18591279]CEM-SS cells:TC50=22.7 µM.(TC50:the concentration that reduced cell viability by 50%)

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2008 Sep 52(9):3438-40.