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Peptide record

TPDB20071

Antibacterial Anticancer Toxicity modified_plain modified
14 amino acids
Basic Information
3D PDB MODEL
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TPDB20071
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 14-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
GIIXXIIXXIIXXI
Physicochemical Analysis
C44H82N8O9
ARNDCEQHLKMFPSTWYV
I
867.18
6.02
0
0
7
-0
-2.16
2.221
195.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
7
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 7 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C44H82N8O9
867.18
6.02
-0
-2.16
2.221
Evidence Records 7 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
13 µM
Cytotoxic
50% Cell death | 13 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Amino acid side chains affect the bioactivity of designed short peptide amphiphiles | J Mater Chem B | 2016
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>250 µM
Hemolytic Cytotoxic
50% Hemolysis | >250 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Amino acid side chains affect the bioactivity of designed short peptide amphiphiles | J Mater Chem B | 2016
Evidence 3 Activity

Activity

50% Cell death
Toxicity
4 µM
Cytotoxic
50% Cell death | 4 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Amino acid side chains affect the bioactivity of designed short peptide amphiphiles | J Mater Chem B | 2016
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
50% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Amino acid side chains affect the bioactivity of designed short peptide amphiphiles | J Mater Chem B | 2016
Evidence 5 Activity

Activity

50% Cell death
Toxicity
26 µM
Cytotoxic
50% Cell death | 26 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Amino acid side chains affect the bioactivity of designed short peptide amphiphiles | J Mater Chem B | 2016
Evidence 6 Activity

Activity

HC50
Toxicity
250 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50>250 µM | Cytotoxicity: Human keratinocytes HaCat: <5% Killing=40 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Evidence 7 Activity

Activity

HC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=200 µM | Cytotoxicity: Human keratinocytes HaCat: <5% Killing=40 µM

Target

erythrocytes

Source & Reference

NA
DRAMP