Back to search

Peptide record

TPDB20066

Antibacterial Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB20066
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 45-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GIINTLQKYYCRVRGGRSAVLSSLPKEEQIGKSSTRGRKCSRRKK
Physicochemical Analysis
C216H377N75O63S2
DHMFW
R
5096.95
11.45
13
2
11
+11
13.79
-0.993
67.11
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3105
60.92
15
Residue Composition
number
1
A
7
R
1
N
0
D
2
C
2
E
2
Q
5
G
0
H
3
I
3
L
6
K
0
M
0
F
1
P
6
S
2
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 1 R: 7 N: 1 D: 0 C: 2 E: 2 Q: 2 G: 5 H: 0 I: 3 L: 3 K: 6 M: 0 F: 0 P: 1 S: 6 T: 2 W: 0 Y: 2 V: 2
Chemical Descriptors
45
C216H377N75O63S2
5096.95
11.45
+11
13.79
-0.993
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

LD90 (lethal dose killing > 90%): active against E. coli WBB01 or ATCC 11775 (LD90 0.1 ug/ml), S. enterica sv Minnesota strain R595 or R60 or PXG1 (L90 0.2 ug/ml), P. mirabilis R45 (LD90 12.5 ug/ml), B.cepacia WaaC::kann or ATCC 25416 (LD90 > 100 ug/ml), and P. aeruginosa ATCC 1014 (LD90 0.39 ug/ml). Warning: other bacteria not tested.
Evidence 2 Activity

Activity

12% Hemolysis
Toxicity
150 µg/mL
Hemolytic Cytotoxic
12% Hemolysis | 150 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of disulfide bonds in human beta defensin-3 on its strain specific activity against Gram-negative bacteria. | Biochim Biophys Acta | 2020