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Peptide record

TPDB20065

Antibacterial Anticancer Hemolysis Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB20065
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 45-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
GIINTLQKYYCRVRGGRCAVLSCRSQEYRIGRCSTRGRKCCRRKK
Physicochemical Analysis
C218H378N82O59S6
DHMFPW
R
5284.27
10.99
14
1
11
+13
10.04
-0.844
58.44
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4845
91.69
17
Residue Composition
number
1
A
10
R
1
N
0
D
6
C
1
E
2
Q
5
G
0
H
3
I
2
L
4
K
0
M
0
F
0
P
3
S
2
T
0
W
3
Y
2
V
Amino Acid Distribution
A: 1 R: 10 N: 1 D: 0 C: 6 E: 1 Q: 2 G: 5 H: 0 I: 3 L: 2 K: 4 M: 0 F: 0 P: 0 S: 3 T: 2 W: 0 Y: 3 V: 2
Chemical Descriptors
45
C218H378N82O59S6
5284.27
10.99
+13
10.04
-0.844
Evidence Records 6 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
10 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 10 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Chimeric Cationic Peptide Composed of Human β-Defensin 3 and Human β-Defensin 4 Exhibits Improved Antibacterial Activity and Salt Resistance. | Front Microbiol | 2021
Evidence 2 Activity

Activity

11% Hemolysis
Toxicity
40 µg/mL
Hemolytic Cytotoxic
11% Hemolysis | 40 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Chimeric Cationic Peptide Composed of Human β-Defensin 3 and Human β-Defensin 4 Exhibits Improved Antibacterial Activity and Salt Resistance. | Front Microbiol | 2021
Evidence 3 Activity

Activity

0% Killing
Toxicity
10 µg/mL
Cytotoxic
0% Killing | 10 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
A Chimeric Cationic Peptide Composed of Human β-Defensin 3 and Human β-Defensin 4 Exhibits Improved Antibacterial Activity and Salt Resistance. | Front Microbiol | 2021
Evidence 4 Activity

Activity

53% Killing
Toxicity
40 µg/mL
Cytotoxic
53% Killing | 40 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
A Chimeric Cationic Peptide Composed of Human β-Defensin 3 and Human β-Defensin 4 Exhibits Improved Antibacterial Activity and Salt Resistance. | Front Microbiol | 2021
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Microbiol. 2021 May 7 12:663151.
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis