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Peptide record

TPDB20062

Antibacterial Anticancer Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB20062
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GIIKKIIKKIIKKV
Physicochemical Analysis
C79H152N20O15
ARNDCEQHLMFPSTWY
IK
1622.20
11.21
6
0
7
+6
4.16
0.529
187.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
6
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 6 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
14
C79H152N20O15
1622.20
11.21
+6
4.16
0.529
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
40 µM
Cytotoxic
50% Cell death | 40 | µM | target cell: Human chondrocytes-articular cells HCa

Target

Human chondrocytes-articular cells HCa

Source & Reference

NA
DBAASP
Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity. | ACS Appl Mater Interfaces | 2016
Evidence 2 Activity

Activity

22% Hemolysis
Toxicity
300 µM
Hemolytic Cytotoxic
22% Hemolysis | 300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity. | ACS Appl Mater Interfaces | 2016
Evidence 3 Activity

Activity

35% Hemolysis
Toxicity
500 µM
Hemolytic Cytotoxic
35% Hemolysis | 500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity. | ACS Appl Mater Interfaces | 2016
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
22 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 22% Hemolysis=300 µM Human erythrocytes: 35% Hemolysis=500 µM | Cytotoxicity: Human chondrocytes-articular cells Hca: 50% Killing=40 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Appl Mater Interfaces. 2016 Oct 12 8(40):26501-26510.