TPDB

3D PDB MODEL

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TPDB ID TPDB20061

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GIIKKIIKKIIKKK

FASTA

>TPDB20061|Antibacterial;Anticancer;Toxicity|length=14
GIIKKIIKKIIKKK

Formula C80H155N21O15

Absent Amino Acids ARNDCEQHLMFPSTWYV

Common Amino Acids K

Mass 1651.24

PI 11.29

Basic Residues 7

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +7

Boman Index 5.08

Hydrophobicity -0.050

Aliphatic Index 167.14

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

6

I

0

L

7

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 6 L: 0 K: 7 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

14

Formula

C80H155N21O15

Mass

1651.24

PI

11.29

Net Charge

+7

Boman Index

5.08

Hydrophobicity

-0.050

Evidence 1 Activity

Activity

Activity Endpoint 10% Killing

Detail Source Activity Toxicity

Activity Measurement 40 µM

Toxicity Type Cytotoxic

Toxicity Raw

10% Killing | 40 | µM | target cell: Human chondrocytes-articular cells HCa

Target

Target Cell Human chondrocytes-articular cells HCa

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity. | ACS Appl Mater Interfaces | 2016

Evidence 2 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 500 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 500 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity. | ACS Appl Mater Interfaces | 2016

Evidence 3 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Toxicity

Activity Measurement 0 %

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Human erythrocytes: 0% Hemolysis=500 µM | Cytotoxicity: Human chondrocytes-articular cells Hca: 10% Killing=40 µM

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

ACS Appl Mater Interfaces. 2016 Oct 12 8(40):26501-26510.