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Peptide record

TPDB20059

Antibacterial Anticancer Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB20059
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GIIKKIIKKIIKKA
Physicochemical Analysis
C77H148N20O15
RNDCEQHLMFPSTWYV
IK
1594.15
11.21
6
0
7
+6
3.92
0.357
174.29
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
6
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 6 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C77H148N20O15
1594.15
11.21
+6
3.92
0.357
Evidence Records 4 records
Evidence 1 Activity

Activity

25% Killing
Toxicity
40 µM
Cytotoxic
25% Killing | 40 | µM | target cell: Human chondrocytes-articular cells HCa

Target

Human chondrocytes-articular cells HCa

Source & Reference

NA
DBAASP
Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity. | ACS Appl Mater Interfaces | 2016
Evidence 2 Activity

Activity

5% Hemolysis
Toxicity
300 µM
Hemolytic Cytotoxic
5% Hemolysis | 300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity. | ACS Appl Mater Interfaces | 2016
Evidence 3 Activity

Activity

15% Hemolysis
Toxicity
500 µM
Hemolytic Cytotoxic
15% Hemolysis | 500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity. | ACS Appl Mater Interfaces | 2016
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 5% Hemolysis=300 µM Human erythrocytes: 15% Hemolysis=500 µM | Cytotoxicity: Human chondrocytes-articular cells Hca: 25% Killing=40 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Appl Mater Interfaces. 2016 Oct 12 8(40):26501-26510.