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Peptide record

TPDB20058

Antibacterial Anticancer Hemolysis Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB20058
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
GIFPIFAKLLGKVIKVASSLISKGRTK
Physicochemical Analysis
C136H235N35O32
NDCEQHMWY
K
2872.58
11.85
6
0
13
+6
1.39
0.633
130.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
4
I
3
L
5
K
0
M
2
F
1
P
3
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 4 L: 3 K: 5 M: 0 F: 2 P: 1 S: 3 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
27
C136H235N35O32
2872.58
11.85
+6
1.39
0.633
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
5.0±0.4 µM
Cytotoxic
50% Cell death | 5.0±0.4 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Conformational Analysis of the Host-Defense Peptides Pseudhymenochirin-1Pb and -2Pa and Design of Analogues with Insulin-Releasing Activities and Reduced Toxicities. | J Nat Prod | 2015
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
4±1 µM
Hemolytic Cytotoxic
50% Hemolysis | 4±1 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Conformational Analysis of the Host-Defense Peptides Pseudhymenochirin-1Pb and -2Pa and Design of Analogues with Insulin-Releasing Activities and Reduced Toxicities. | J Nat Prod | 2015
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: Mouse erythrocytes:50% Hemolysis=4±1µM | Cytotoxicity: HUVEC: 50% Cell death=5.0±0.4µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Nat Prod. 2015 Dec 24 78(12):3041-8.
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis