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Peptide record

TPDB20057

Antibacterial Anticancer Antifungal Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB20057
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 dbACP
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, and dbACP, with an available 3D structural model.
Sequence
GIFKVLKNLAKGVITSLKS
Physicochemical Analysis
C94H166N24O24
RDCEQHMPWY
K
2016.50
11.00
4
0
9
+4
1.34
0.589
138.42
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
3
L
4
K
0
M
1
F
0
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 3 K: 4 M: 0 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
19
C94H166N24O24
2016.50
11.00
+4
1.34
0.589
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 3.12 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S.
Evidence 2 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 3.12 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 6.25uM), S. epide
Evidence 3 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

A. baumannii ATCC 19606

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 3.12 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 6.25uM), S. epidermidis ATCC 12228 (MIC 1.56 uM), B. meg
Evidence 4 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

uM), P. aeruginosa ATCC 27853 (MIC 3.12 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 6.25uM), S. epidermidis ATCC 12228 (MIC 1.56 uM), B. megaterium BM11 (MIC Conlon et al., 2022 ).
Evidence 5 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

NA

Other

3.12 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 6.25uM), S. epidermidis ATCC 12228 (MIC 1.56 uM), B. megaterium BM11 (MIC Conlon et al., 2022 ).
Evidence 6 Activity

Activity

MIC
Antifungal
6.25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 3.12 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S.
Evidence 7 Activity

Activity

MIC
Antifungal
3.12 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 3.12 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 6.25uM), S. epide
Evidence 8 Activity

Activity

MIC
Antifungal
1.56 µM

Target

A. baumannii ATCC 19606

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 3.12 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 6.25uM), S. epidermidis ATCC 12228 (MIC 1.56 uM), B. meg
Evidence 9 Activity

Activity

MIC
Antifungal
6.25 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

uM), P. aeruginosa ATCC 27853 (MIC 3.12 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 6.25uM), S. epidermidis ATCC 12228 (MIC 1.56 uM), B. megaterium BM11 (MIC Conlon et al., 2022 ).
Evidence 10 Activity

Activity

MIC
Antifungal
1.56 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

NA

Other

3.12 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 6.25uM), S. epidermidis ATCC 12228 (MIC 1.56 uM), B. megaterium BM11 (MIC Conlon et al., 2022 ).
Evidence 11 Activity

Activity

LC50
Toxicity
28±4 µM
Cytotoxic
LC50 | 28±4 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Antimicrobial, cytotoxic, and insulin-releasing activities of the amphibian host-defense peptide ocellatin-3N and its L-lysine-substituted analogs. | J Pept Sci | 2022
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
50% Hemolysis | >128 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial, cytotoxic, and insulin-releasing activities of the amphibian host-defense peptide ocellatin-3N and its L-lysine-substituted analogs. | J Pept Sci | 2022
Evidence 13 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2023 Apr 29(4):e3466.